Once upon a time in the far away kingdom of Dor lived a brave and virtuous mouse with comically oversized ears who dreamt of becoming a knight. Banished from his home for having such lofty ambitions, Despereaux sets off on an amazing adventure with his good-hearted rat friend Roscuro. The two go on a very noble quest to rescue an endangered princess and save an entire kingdom from darkness.

When Jerry moves into a fine hotel on the eve of an important society wedding, the event planner hires Tom to get rid of him. Unfortunately, the battle which follows is big enough to destroy the wedding, her career, and possibly the hotel -- so the sworn enemies decide to work together to save it all.

Once upon a time in the far away kingdom of Dor lived a brave and virtuous mouse with comically oversized ears who dreamt of becoming a knight. Banished from his home for having such lofty ambitions, Despereaux sets off on an amazing adventure with his good-hearted rat friend Roscuro. The two go on a very noble quest to rescue an endangered princess and save an entire kingdom from darkness.